KNEE & HIP REGENERATION
“I am always moved to comment when I hear people discussing stem cell therapy. I had my knees treated with stem cells using the Pak Method, and it has been nothing short of amazing.
This is the real deal.” -JPV, Australia
Life is motion. The ability to move with ease, confidence and comfort is something that everyone would like to be able to take for granted. It goes without saying that one measure of aging is the degree of infirmity (from aches & pains to crippling immobility) that often come with the passing years. With the advent of knee and hip joint replacement surgery, and with costs for soaring to as high as $125,000 per procedure, ‘hammer & chisel’ surgery has provided patients with new measures of pain when they consider an artificial joint with a 10-15 year life-span.
Mesenchymal Stem Cells (MSCs) are the ‘repair stem cells’ of the knee and hip, and a measure of aging is how plentiful they are, and how well they do their job. Not surprisingly, these repair cells decrease in numbers and vitality as people age. Thus, an obvious way to describe typical arthritis of the knee and hip is as an MSC deficiency: a deficiency of repair stem cells is the key problem. Is the obvious solution to a repair stem cell deficiency a hammer & chisel? Probably not.
The most obvious, elegant and natural solution to a shortage of repair stem cells is to replace them, to augment their numbers with new stem cells from either host or donor. These replacement cells have the ability to 1) home (go to where they are needed); 2) integrate (blend in with the cells that are already there); 3) differentiate/proliferate (generate new bone and cartilage-producing cells).
Ten years ago this was the future: the future is now. Today we have available the treatments that are becoming the preferred front-line therapy for some of the most common (and costly) forms of orthopedic diseases of the knee and hip. These treatments have been pioneered by Dr. Jae W. Pak and his team in Seoul, South Korea.
Dr. Pak is an extremely well-trained (USA) Regenerative Medicine specialist living and working in Korea. He and his team have pioneered repair stem cell replacement biotechnology over the past several years. In this important work, they have treated nearly 1,000 patients and published a series of important and ground-breaking medical papers.
The original Pak Method (Pak-I) has be used successfully to manage over 800 knee and hip cases using stem cells that were first harvested from the hos-patient, then concentrated and re-injected into the hip, or the knee joint, of the host-patient. The initial stem cell injections were followed platelet-rich plasma injections (also from the donor-patient) in the ensuing days.
The specific diagnostic groups are as follows:
(1) Hip disease: Osteonecrosis (Avascular Necrosis, or AVN) of the hip
(2) Knee disease:
a) Osteoarthritis (aging arthritis) of the knee
b) Meniscus tear, knee
c) Chondromalacia patellae, knee
The diagnosis of AVN of the hip is notable for being a crippling and painful disease of relatively young persons (30-50). Since these patients are too young to be appropriate candidates for total hip surgery, the Pak Method is the most appropriate initial therapy.
In treating diseases of the knee with repair stem cells, patients receive a safe, relatively painless and cost-effective procedure that has the potential to mitigate (perhaps indefinitely) against the need for expensive, potentially risky, and relatively painful hammer and chisel surgery.
Dr. Jae W. Pak
Jae W. Pak, MD, Regenerative Medicine
•University of California, Berkeley
•University of Southern California School of Medicine
•American National Board of Medicine
•California Medical Licensure
•UCLA VA Medical Center Training
•Board Member, Korean Medical Law Society
•Harvard Medical School Regenerative Medicine CME
•IRB Board Member, International Cellular Medicine Society
•Member, International Federation of Adipose Therapeutics and Science
•Member, American Academy of Pain Management
•Member, Society of Anti-Aging
* OA of knees and hips & AVN of femoral heads treated using autologous adipose (fat) tissue-derived stem cells.
* Over 800+ procedures including successful treatments of osteoarthritis and AVN of femoral heads .
2011 Case Report of the Year Award by BioMedCentral (BMC)
Publications by Jae W. Pak, MD:
1. Regeneration of Bones in Hip Osteonecrosis and Cartilage in Knee Osteoarthritis with adipose tissue-derived stems cells in human. Journal of Medical Case Reports July 2011.
2. Autologous Adipose Tissue-Derived Stem Cells Induce Persistent Bone-Like Tissue in Osteonecrotic Femoral Heads. Pain Physician Jan/Feb 2012, vol 15, issue 1, Page 75-85
3. A novel biological approach to treat chondromalacia patellae. PLOS ONE May 2013. PLoS ONE 8(5): e64569.
4. BMC Musculoskeletal disorders 2013, J. Pak et al. Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet-rich plasma into human articular joints. BMC Musculoskeletal Disorders 2013, 14:337
5. BioMed Research International Review Article "Regenerative repair of damaged meniscus with autologous adipose-tissue-derived stem cells," BioMed Research International, vol. 2014, Article ID 436029, 10 pages, 2014.
The Pak-I Method: separation and concentration of adipose-derived stem cells (ADSCs) and re-injection to knee or hip of donor-patient. This followed by PRP injections over several ensuing days.
The Pak-II Method: separation, purification and amplification (culturing) of host stem cells from peripheral blood and re-injection to knee or hip of donor-patient 3-4 weeks later. This followed by PRP injections over several ensuing days.
The Pak-III Method: direct injection of pre-determined number of donor MSCs into knee or hip, followed by PRP injections over several ensuing days.